益生菌及其代谢产物功能研究

科研项目：

2020.01-2023.12   国家自然科学基金青年项目“胞外多糖介导的生物被膜态乳杆菌调节肠道黏膜免疫的机制研究（32001663）”，负责人

2019.01-2021.12   教育部项目“群感抑制剂对发酵泡菜腐败菌群结构的调控作用研究”，负责人

2018.01-2019.12   北京市重点实验室开放课题“发酵泡菜环境下群感抑制剂对腐败菌群的调控作用”，负责人

2020.01-2021.12   北京市重点实验室开放课题“新型益生菌制剂对机体肠道菌群及代谢的影响研究”，负责人

2017.01-2020.12   国家自然科学基金面上项目“LuxS/AI-2群体感应系统调控益生乳杆菌生物被膜形成的分子机制（31671831）”，主要参与人

2019.01-2021.12   四川省科技厅应用基础项目“四川泡菜微生物安全和腐败防控新策略——基于菌剂拮抗和超高压灭菌的多靶栅栏技术研究2019YJ0388”，主要参与人

2021.01-2023.12   四川省科技厅项目“葛根精加工开发转化关键技术及产业2021NZ0568”，主要参与人

发表文章

1、Lei Liu, Shuyu Guo, Xing Chen, Shuhui Yang, Xi Deng, Mingxia Tu, Yufei Tao, Wenliang Xiang and Yu Rao*. Metabolic profiles of Lactobacillus paraplantarum in biofilm and planktonic states and investigation of its intestinal modulation and immunoregulation in dogs. Food & Function, 2021, 12: 5317-5332. (JCR 1区, IF 5.396)

2、Yu Rao, Yufei Tao, Xing Chen, Xiao She, Yang Qian, Yalin Li, Yuwei Du, Wenliang, Xiang, Hehe Li*, Lei Liu*. The characteristics and correlation of the microbial communities and flavors in traditionally pickled radishes. LWT- Food Science and Technology, 2020, 118: 1-8. (JCR 1区, IF 4.952 )

3、Lei Liu, Xiao She, Xing Chen, Yang Qian, Yufei Tao, Yalin Li, Shuyu Guo, Wenliang Xiang, Guorong Liu* and Yu Rao*. Microbiota succession and chemical composition involved in the radish fermentation process in different containers. Frontiers in Microbiology, 2020, 11:445. (JCR 2区, IF 5.640)

4、Lei Liu, Xiao She, Yang Qian, Yalin Li, Yufei Tao, Zhenming Che, Guorong Liu* and Yu Rao*. Effect of different fermenting containers on the deterioration of Sichuan pickle. LWT- Food Science and Technology, 2019, 111:829-836. (JCR 1区, IF 4.952 )

5、Yu Rao, Yufei Tao, Yalin Li, Xiao She, Jiantao Yang, Yang Qian, Hengjun Du, Lei Liu* and Hang Xiao*. Characterization of a probiotic starter culture with anti-Candida activity for Chinese pickle fermentation. Food & Function, 2019, 10: 6936-6944.  (JCR 1区, IF 5.396)

6、Zhengqiu Li, Lei Liu*, Baoshu Chen, Tianbao Zhao, Longchang Ran, Xiaodie Yuan, Zhiwen Cao, Ting Wu. Structure and antimicrobial properties of long-chain branched poly (lactic acid). Journal of Biomedical Materials Research Part A, 2019, 107: 2458-2467. (JCR 2区, IF 4.396)

7、Lei Liu, Ruiyun Wu, Jinlan Zhang, Pinglan Li*. Overexpression of luxS promotes stress resistance and biofilm formation of L-ZS9 by regulating the expression of multiple genes. Frontiers in Microbiology, 2018, 9: 2628.  (JCR 2区，IF5.640)

8、Lei Liu, Ruiyun Wu, Jinlan Zhang, Nan Shang, Pinglan Li*. D-ribose interferes with quorum sensing to inhibit biofilm formation of Lactobacillus paraplantarum L-ZS9. Frontiers in Microbiology, 2017, 8:1860.  (JCR 2区，IF5.640)

9、Lei Liu, Hui Li, Rihua Xu Pinglan Li*. Expolysaccharides from Bifidobacterium animalis RH activates RAW 264.7 macrophages through toll-like receptor 4. Food and Agricultural Immunology, 2016, 28: 149-161. (JCR 2区，IF3.101）

10、Lei Liu, Pinglan Lan*. Complete genome sequence of Lactobacillus paraplantarum L-ZS9, a probiotic starter producing class II bacteriocins. Journal of Biotechnology, 2016, 222: 15-16. (JCR 3区）

11、Lei Liu, Yuxuan Qin, Yang Wang, Hui Li, Nan Shang, Pinglan Li*. Complete genome sequence of Bifidobacterium animalis RH, a probiotic bacterium producing exopolysaccharides. Journal of Biotechnology, 2014, 189: 86-87. (JCR 3区）

12、陈星, 郭书玉, 陶雨飞, 邓西, 杨淑慧, 涂明霞, 吴艾玲, 马偲臆, 饶瑜, 刘蕾*. 糖酵解途径相关基因与植物乳杆菌生理行为的相关性（英文）.食品科学，2021,42(22):113-124. (EI)

13、刘蕾，李娅琳，聂蓉，钱杨，厍晓，陶雨飞，饶瑜*. D-核糖及肉桂醛对四川泡菜菌群多样性和生物被膜的影响. 食品科学, 2019,40(22):53-60. (EI)

14、刘蕾，厍晓，钱杨，李娅琳，聂蓉，饶瑜*. tuf基因同源超表达对植物乳杆菌LR-1生理行为的影响. 食品科学，2019,40(8):48-55. (EI)

15、刘蕾, 刘义, 李平兰*. 益生菌生物被膜的研究进展. 食品科学. 2016, 37(9): 214-219. (EI)

16、刘蕾, 武瑞赟, 李军, 李平兰*. 类植物乳杆菌L-ZS9生物被膜态的黏附能力及形成影响因素. 食品科学. 2016, 37(15): 136-143. (EI)

17、刘蕾, 桂萌, 武瑞赟, 李平兰*. LuxS/AI-2型群体感应系统调控细菌生物被膜形成研究进展. 食品科学. 2016, 37(19): 255-263. (EI)

18、刘蕾, 韩先干, 刘瑞, 白灏, 董洪亮, 丁铲, 刘海文, 于圣青*. AI-2对鸭疫里氏杆菌粘附入侵Vero细胞及其相关基因转录水平的影响. 微生物学报. 2013, 53(3): 313-318.